172 CLINICAL AND PROGNOSTIC IMPLICATIONS OF RV UPTAKE WITH RADIONUCLIDE SCINTIGRAPHY IN TRANSTHYRETIN CARDIAC AMYLOIDOSIS
نویسندگان
چکیده
Abstract Aims The prognostic role of bone tracer uptake in transthyretin cardiac amyloidosis (ATTR-CA) is controversial. study investigated the potential significance biventricular (BiV) ATTR-CA. Methods Consecutive ATTR-CA patients who had scintigraphy with acquisition planar and single-photon emission computed tomography (SPECT) images from National Amyloidosis Centre (NAC) four Italian centres were included. Planar BiV was defined presence right ventricle (RV) graded combination SPECT imaging. primary outcome all-cause mortality. Results Among 1422 ATTR-CA, found 85% cases on 100% images. During a median follow-up 39 months, at associated higher mortality compared to isolated LV (40.5% vs 10.7%, p<0.001), whereas Perugini scale not (p=0.27 grade 2 3). At multivariable analysis, RV leading (HR 2.80, p=0.001), together age diagnosis 1.03, V122I TTR variant 1.60, NAC ATTR Stage 1.29, p=0.003), E/e’ 1.02, p=0.044), atrium area index 1.04, p=0.018) GLS 1.05, p=0.003) independently death. time-dependent ROC curve addition stage resulted improved accuracy model for prediction death (from AUC 0.74 0.79; p<0.001). Conclusions identified worse outcome, potentially serving as novel marker.
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2022
ISSN: ['1520-765X', '1554-2815']
DOI: https://doi.org/10.1093/eurheartjsupp/suac121.667